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What Drugs Should Not Be Taken with CBD Gummies?

December 16, 2022 5 min read

What Drugs Should Not Be Taken with CBD Gummies?

What Drugs Should Not Be Taken with CBD Gummies?

Some drugs prescribed or supplements can negatively interact with CBD gummies. This blog discusses what drugs should not be taken with CBD gummies, including; what they are, how they can affect some drugs, and the side effects.

CBD is a short name for Cannabidiol. It is an active compound extracted from the leaves and flowers of the hemp plant. The cannabis strain is most preferred since it contains a high concentration of CBD molecules and a low amount of THC. CBD can react with prescribed or over-the-counter medications such as sedatives or opioids. Some medications are cancer prescriptions used in therapy sessions or hormonal treatments. Cannabis products like gummies may reduce the reliance on some medications CBD interacts with.

What Are CBD Gummies?

CBD gummies are sweet candies in different shapes, sizes, and flavors. They contain CBD oil as the main active ingredient. They allow users to harness the therapeutic benefits of CBD with a delicious flavor by masking the oily bitter taste associated with cannabis products. Tetrahydrocannabinol (THC) is another popular cannabinoid that induces a feeling of highness in its users. Unlike THC, CBD has no mind-altering effects and is highly diluted with an organic carrier oil before being incorporated into other products' ingredients. CBD gummies are added to other ingredients like gelatin in the final hardening stage.

How CBD Gummies Can Affect Certain Medications

CBD gummies can treat symptoms of certain body complications. However, CBD is an active compound that can easily react negatively with certain prescribed drugs or supplements. According toBrown et al. (2019), there are three ways CBD can affect how some drugs behave in the human body:

  • Karaźniewicz-Łada et al. (2021) suggested that CBD interferes with the metabolism of certain drugs in the liver. It desensitizes enzymes like cytochrome. As a result, these drugs' level increases significantly, as they are not entirely metabolized, causing unwanted side effects.
  • Oberbarnscheidt& Miller (2020) showed thathigh doses of CBD gummies could cause an increase in the sedative effects of certain prescribed medications affecting the central nervous system. The most affected drugs are antidepressants causing excessive dopamine production if taken together with CBD.
  • CBD therapeutic properties like immunomodulatory and anti-inflammatory can react negatively with other drugs with the same capability.

9 Drugs that Negatively WithCBD Gummies

Boehnke et al. (2021) explained that using opioids such as morphine with CBD gummies can make your breathing system more susceptible to severe side effects like respiratory depression and breathing issues. Taking CBD can help in treating respiratory discomforts and reduce the intake of using opioid-based pain relievers.


Some immunosuppressives like teriflunomide can affect liver detoxicating functions. Using CBD products can increase risks and weaken liver function.


Belcaro (2016) claimed that whencorticosteroids are taken with cannabis products like CBD gummies, they inhibit the production of the enzyme cytochrome used to boost the body's metabolic rate. The clearance of these drugs from the system is delayed, increasing the risk of adverse effects like dizziness, drowsiness, etc.

Thyroid Medications

Taking thyroid medications with CBD gummies can cause the drug not to be metabolized properly. As a result, a build-up of thyroxine causes complications in digestion, heart functions, and the muscular system.


Brown &Winterstein (2019) showed that consuming CBD gummies with antidepressants like Prozac can affect the production of liver enzymes metabolizing these drugs. Their interaction resultsina decreased or increased amount of the drug in the body,causing under or overdosing. As a result, there may be increased dizziness, sedation, or headaches. Crippa et al. (2019) revealed that CBD could help alleviate depression and anxiety by increasing dopamine and serotonin production.

Non-steroidal Anti-inflammatory Drugs ( NSAIDs)

Using CBD products and non-steroidal anti-inflammatory drugs like diclofenac makes your body more prone to complications like stomach bleeding, liver problems, or stomach upset.Consume highly potent CBD gummies to reduce body inflammations affecting the digestive tract.

Antiplatelets and Anticoagulants

The most common anticoagulant drug is warfarin. Ithelps in blood clotting boosting wound healing. According to Best et al. (2022), taking warfarin with CBD products can cause blood thinning making wounds more susceptible to bruising. Like other medications, CBD inhibits the breakdown of antiplatelets, increasing their levels in the circulatory system.


Consuming CBD gummies with benzodiazepines like Lorazepam can make your body more susceptible to side effects like lack of concentration, confusion, drowsiness, and dizziness. These medications treat mental disorders like anxiety, seizures, and depression. However, they are metabolized by specific liver enzymes CBD desensitizes. As a result, their excessive accumulation can have some adverse and sub-therapeutic effects.


CBD acts as anantipsychotic agent to treat symptoms of psychosis. They include sleeplessness, hallucinations, dementia, and fatigue. Antipsychotic drugs like aripiprazole can do the same. However, taken together with CBD can have some undesirable side effects. The interaction of the two causes the psychosis symptoms to worsen.

What Are the Potential Side Effects of Consuming CBD Gummies?


Drowsiness is an excessive feeling of fatigue and sleepiness during the day. Overdosing with CBD gummies means overworking your body receptors, suppressing the body's energy.

Dry Mouth

Liu (2019) suggested that CBD drinks may cause dry or cotton mouth. It reduces the production of saliva by the mouth glands.

Nausea and Vomiting

According toGrimison et al. (2020), vomiting or nausea are common side effects for beginners in the CBD regime. It is because their body systems try to adapt to CBD's therapeutic effects, resulting in stomach irritations.


Dizziness is the most common adverse effect when you overdose on any medications, either prescribed or a supplement. CBD gummies are not exceptional; overdosing on them means your body receptors try to interact with the CBD compounds resulting in a feeling of dizziness.


Gummies are a popular way to take CBD with a delicious flavor by masking the oily, grassy taste associated with cannabis. They treat body imbalances like pain, sleep, anxiety, stress, and depression. Although they have short-lived side effects, CBD gummies have some complications. Patients suffering from serious health problems like seizures, depression, or other mental issues should be cautious while taking CBD with the prescribed medications. Consult your medical cannabis doctor before taking any medication with CBD gummies to avoid some prolonged side effects like diarrhoea, dizziness, and sleeplessness.


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Brown, J. D., &Winterstein, A. G. (2019). Potential Adverse Drug Events And Drug-Drug Interactions With Medical And Consumer Cannabidiol (CBD) Use. Journal Of Clinical Medicine, 8(7), 989.

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Crippa, J. A. S., Hallak, J. E., Zuardi, A. W., Guimarães, F. S., Tumas, V., & Dos Santos, R. G. (2019). Is Cannabidiol The Ideal Drug To Treat Non-Motor Parkinson's Disease Symptoms? European Archives Of Psychiatry And Clinical Neuroscience, 269(1), 121-133.

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Karaźniewicz-Łada, M., Główka, A. K., Mikulska, A. A., &Główka, F. K. (2021). Pharmacokinetic Drug-Drug Interactions Among Antiepileptic Drugs, Including CBD, Drugs Used To Treat COVID-19 And Nutrients. International Journal Of Molecular Sciences, 22(17), 9582.

Liu, T. (2019). What Is CBD Oil? Learn The Facts: Uses, Benefits, And Side Effects.

Oberbarnscheidt, T., & Miller, N. S. (2020). The Impact Of Cannabidiol On Psychiatric And Medical Conditions. Journal Of Clinical Medicine Research, 12(7), 393.